The effect of glycosylated hemoglobin on serum level of plasminogen activator inhibitor-1 in patients with early diabetic nephropathy
10.3760/cma.j.issn.1673-4904.2009.03.001
- VernacularTitle:糖化血红蛋白对糖尿病肾病早期患者纤溶酶原激活物抑制物-1的影响
- Author:
Ling FANG
;
Jianting ZHONG
;
Xiaohui YU
;
Zhihua ZHAO
- Publication Type:Journal Article
- Keywords:
Diabetic nephropathies;
Hemoglobin A,glycosylated;
Tissue plasminogen activator;
Plasminogen activator inhibitor-1
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(3):1-3
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the effect ofglycesylated hemoglobin(GHbA,c) on tissue-type plasminngen activator (t-PA)and level of serum plasminogen activator inhibitor-1 (PAI-1) in patients with early diabetic nephropathy (DN).MethodNinety patients with early DN from April 2004 to May 2005 were divided into 3 groups according to the level of GHbA1c,which was respectively less than 7% (group A),between 7% and 9% (group B),and more than 9% (greup C).Thirty healthy adults were chosen as control group.The levels of serum GHbA1c,t-PA and PAI-1 were detected on empty stomach in the morning.Results The level of serum t-PA was lower,the activity of PAI-1 was higher in groups of DN than those in control group (P＜0.05 or＜0.01),and those were changed with the level of GHbA,c.There were significant differences between group C and group A[t-PA:(0.14± 0.06),(0.28± 0.11) U/ml; PAI-1 (3.25 ±1.01),(1.90q± 1.09) U/ml](P＜0.05).Conclusions The fibrinolytic system exists unbalance in patients with early DN.Continuous hyperglycemia in patients with early DN make unbalanced fibrinolytic system more serious.Controlling the level of GHbA1c strictly can play an important role in delaying DN progress.
