The research of acetated Ringer solution and succinylated gelatin in the fluid resuscitation of sepsis patients
10.3760/cma.j.issn.1673-4904.2009.03.012
- VernacularTitle:醋酸林格液联合琥珀酰明胶用于脓毒症的液体复苏研究
- Author:
Xiujie YANG
;
Huiju BU
;
Xiaomao LIN
;
Haiyang WEN
;
Liang CHEN
- Publication Type:Journal Article
- Keywords:
Sepsis;
Acetated Ringer solution;
Succinylated gelatin;
lactic acid Ringer solution;
Hetastarch
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(3):30-32
- CountryChina
- Language:Chinese
-
Abstract:
Objective To research the clinical significance of acetated Ringer solution and succinylated gelatin in the fluid resuscitation of sepsis patients.Method Fifty-nine sepsis patients were divided into two groups:lactic acid Ringer solution and hetastarch (group A,27 cases)and acetated Ringer solution and suecinylated gelatin (group B,32 cases),compared the fluid resuscitation and other parameter.Results There were no significant difference in the central venous pressure,mean arterial pressure and the dose of noradrenaline (P ＞ 0.05).The activated partial thrombeplastin time in group A was longer than that in group B[(58±10),(74±13)s vs(48±7),(54 ±11) s in 6,24 hours],fibrinogen concentration was lower than that in group B [(3.3 ±0.8),(1.6±0.3)g/L vs (4.2±1.1),(2.1±0.2)g/L in 6,24 hours] (P＜0.05).Serum lactic acid,creatinine,calcium concentration in group A [(6.9±0.8)retool/L,(289 ~ 27)μ mol/L,(2.1 ±0.3)mmol/L]were higher than those in group B [(3.2 ±1.1)mmol/L, (193 ±42)μmol/L, (1.7±0.2)mmol/L](P＜0.05),there was no difference in APACHE Ⅲ scores on the third day between two groups (P＞0.05).Conclusions Acetated Ringer solution and succinylated gelatin in the fluid resuscitation of sepsis patients has the same effect,but fewer impacts on serum coagulation,serum lactic acid and renal function than lactic acid Ringer solution and hetastareh.They may be more suitable for fluid resuscitation of sepsis patients,but hypecalcemia is easy to happen,and there is no significant evidences proving the prognosis.
