The study of B-type natriuretic peptide in evaluating left ventricular function of elderly hemodialysis patients

VernacularTitle:B型利钠肽对老年维持性血液透析患者左心功能评估的临床研究
Author: Xuebo CHEN ; Shuidi ZHU ; Yuwen HU ; Guangyu WU
Publication Type:Journal Article
Keywords: Natriuretic peptide,brain; Renal dialysis; Ventricularfunction,left
From: Chinese Journal of Postgraduates of Medicine 2009;32(6):10-13
CountryChina
Language:Chinese
Abstract: Objective To detect the relationship between plasma B-type natriuretic peptide(BNP) and left ventricular function in elderly patients with maintenance hemodialysis (MHD). Method Plasma BNP concentration were measured in 50 MHD patients (MHD group) and 30 healthy controls (control group). Echocardiographic examinations were performed including left ventricular ejection fraction (LVEF). Results The median plasma BNP level in MHD group before and after hemodialysis was 213.5 ng/L and 110.2 ng/L, and obviously higher than that in control group (20.2 ng/L) (P<0.01). Spearman rank correlation showed that plasma BNP level was significantly negatively correlated with LVEF (r=-0.4357, P< 0.05). The median plasma BNP level in the patients with LVEF < 50% before and after hemodialysis was 386.5 ng/L and 232.0 ng/L, significantly higher than that in the patients without left ventricular dysfunction (LVEF≥50%) (59.7 ng/L and 29.1 ng/L)(P<0.01). Conclusions The level of BNP may reflect dynamic change of left ventricular function in MHD patients. It can help to diagnose and treat cardiovascular disease in MHD patients early.