Delta-like ligand 4 and tumour angiogenesis
10.3760/cma.j.issn.1673-4203.2009.02.016
- VernacularTitle:Delta样配体4与肿瘤血管生成的研究进展
- Author:
Baohua LI
;
Zongfang LI
- Publication Type:Journal Article
- Keywords:
liver stem cells;
liver cancer stem cells;
hepatocellular carcinoma
- From:
International Journal of Surgery
2009;36(2):116-119
- CountryChina
- Language:Chinese
-
Abstract:
Delta-like ligand 4(Dll4), one ligand of Notch receptors, is highly expressed in tumour vessels and is negative regulator in tumour angiogenesis. Blocking Dll4/Notch sinaling could promote tumour angiogenesis, whereas due to poor perrusion of newly forming vessels, tumour growth is inhibited, which is effective even to the tumour patients unresponsive to blocking vascular endothelial growth factor pathway. So, Dll4 is becoming a new promising target in anti-tumour theraties.
