Neurocognitive Changes and Their Neural Correlates in Patients with Type 2 Diabetes Mellitus.
10.3803/EnM.2014.29.2.112
- Author:
Junghyun H LEE
1
;
Yera CHOI
;
Chansoo JUN
;
Young Sun HONG
;
Han Byul CHO
;
Jieun E KIM
;
In Kyoon LYOO
Author Information
1. College of Pharmacy and Graduate School of Pharmaceutical Sciences, Ewha Womans University, Seoul, Korea. inkylyoo@ewha.ac.kr
- Publication Type:Review
- Keywords:
Diabetes mellitus, type 2;
Cognition disorders;
Dementia;
Hyperglycemia;
Hypoglycemia;
Magnetic resonance imaging;
Magnetic resonance spectroscopy
- MeSH:
Atrophy;
Brain;
Cognition Disorders;
Dementia;
Diabetes Mellitus, Type 2*;
Diagnosis;
Humans;
Hyperglycemia;
Hypoglycemia;
Life Expectancy;
Magnetic Resonance Imaging;
Magnetic Resonance Spectroscopy;
Neuroimaging;
Prevalence;
Vascular Diseases
- From:Endocrinology and Metabolism
2014;29(2):112-121
- CountryRepublic of Korea
- Language:English
-
Abstract:
As the prevalence and life expectancy of type 2 diabetes mellitus (T2DM) continue to increase, the importance of effective detection and intervention for the complications of T2DM, especially neurocognitive complications including cognitive dysfunction and dementia, is receiving greater attention. T2DM is thought to influence cognitive function through an as yet unclear mechanism that involves multiple factors such as hyperglycemia, hypoglycemia, and vascular disease. Recent developments in neuroimaging methods have led to the identification of potential neural correlates of T2DM-related neurocognitive changes, which extend from structural to functional and metabolite alterations in the brain. The evidence indicates various changes in the T2DM brain, including global and regional atrophy, white matter hyperintensity, altered functional connectivity, and changes in neurometabolite levels. Continued neuroimaging research is expected to further elucidate the underpinnings of cognitive decline in T2DM and allow better diagnosis and treatment of the condition.
