Distribution of uranium in rata inhaled with depleted uranium aerosols
10.3760/cma.j.issn.0254-5098.2009.01.007
- VernacularTitle:大鼠吸入贫铀气溶胶后体内铀的分布
- Author:
Xiujie PAN
;
Zhihua YANG
;
Zhenshan CAO
;
Ping LI
;
Gang LIU
;
Zhongmin CHEN
;
Han WEI
;
Maoxiang ZHU
- Publication Type:Journal Article
- Keywords:
Depleted uranium;
Aerosols;
Inhalation
- From:
Chinese Journal of Radiological Medicine and Protection
2009;29(1):23-26
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the distribution of uranium in rats after inhalation with depleted uranium aerosols. Methods The depleted uranium aerosols were inhaled by Wistar rats. At 30, 90, 180, 270, 360, and 540 d after inhalation, the rata were sacrificed and tissue samples were collected. The contents of uranium in lung, kidney, liver, heart, brain, thighbone, spleen and thymus were measured by laser time-dependent spectroscopy analysis. Resulits The uranium contents of lung increased in the high-dosc and low-dose groups [(499833.3 ± 14214.8) ng/g and (25 424.0 ± 6193.4)ng/g, respectively] after inhalation, and significantly differed from the control (28.8 ± 13.9)ng/g, (P < 0.05).At 30 d after inhalation, the contents of uranium in lung, kidney and thighbone were higher than those of control, and then decreased time-dependently. At 60 d, the contents of uranium in liver, heart, brain, spleen and thymus were higher than those of control. Curve of the eontenta were biphasie, whieh went up first, reached at peak value and then went down. The contents of uranium were high in lung, thighbone, brain and thymus. Conclusions After inhalation of depleted uranium aerosols, lung and thighbone are the primary reservoirs for uranium redistributed, and accumulations in brain and thymus suggest other two organs for unanticipated injury by depleted uranium.
