The analysis of effect about different therapies on brain metastases from non-small cell lung cancer
10.3760/cma.j.issn.0254-5098.2009.01.022
- VernacularTitle:非小细胞肺癌脑转移不同治疗方法的疗效分析
- Author:
Yaping XU
;
Shenglin MA
;
Yongling JI
;
Xinmin YU
;
Yang YU
;
Xiaojiang SUN
;
Shengye WANG
- Publication Type:Journal Article
- Keywords:
Lung neoplasms;
Neoplasm metastasis;
Brain;
Combined modulated therapy;
Prognosis
- From:
Chinese Journal of Radiological Medicine and Protection
2009;29(1):71-74
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the prognostic factors of brain metastasis from non-small cell lung cancer and suggest a individualized treatment method proposal with prognostic estimation. Methods From Dec. 2003 to Jan.2007, 183 patients received whole brain radiation therapy (WBRT) were retrospectively analyzed. Kaplan-Meier method was used to analyze the survival. Logrank test was used to evaluate the difference between the groups. Multivariate survival analysis was conducted using a Cox proportional hazard regression model with a backward stepwise procedure. Results The overall l-, 2- and 3-year survival rate was 40.6%, 16.6% and 11.3%, respectively, but with a median survival time of 10.0 months (95% CI 8.6-11.4 months). In multivariate analysis, RAP grouping, weight loss, LDH in blood serum and treatment method were independent prognostic factors. The median survival time of WBRT alone, WBRT with chemotherapy, surgery with chemoradiotherapy and WBRT with Gefitinib was 9.0, 9.0, 22.0 and 13.0 months, respectively, but their difference were statistical significant (X2 = 10.37, P = 0.016). Conclusions The main prognostic factors of brain metastasis from non-small cell lung cancer are RAP grouping, weight loss, LDH in blood serum and treatment method. The survival time is prolonged by proper multidiseiplinary management than WBRT alone. The effect of combined treatment of surgery with chemoradiotherapy is favorable for the patients operated with single region of metastasis.
