The recent effects of concurrent versus sequential chemo-radiotherapy in locally advanced non-small-cell lung cancer
- VernacularTitle:局部晚期非小细胞肺癌同步与序贯放化疗的近期疗效观察
- Author:
Haichen ZHANG
;
Guoquan LL
;
Lijuan ZOU
- Publication Type:Journal Article
- Keywords:
Sequential chemo-radiotherapy;
Concurrent chemo-radiotherapy;
Carcinoma,non-small-cell lung;
Docetaxel
- From:
Chinese Journal of Postgraduates of Medicine
2008;31(z1):13-15
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the recent effects of concurrent versus sequential chemo-radio-therapy in treatment for locally advanced non-small-cell lung cancer (NSCLC). Methods The clinical data of 39 patients with locally advanced NSCLC were analyzed retrospectively. The sequential therapy was 23 (sequential group) ,and the concurrent therapy (concurrent group)was 16. The total radiation dose was 60 ～ 65 Gy by conventional fractionation radiotherapy. In sequential group,the patients received induction chemotherapy for two cycles followed by conventional radiation therapy. In concurrent group,the patients re-ceived radiation therapy,at the same time the docetaxe was given every week. Results The recent efficien-cy(62.5%) of concurrent therapy was higher than that(43.5% )of sequential therapy. The clinical remission rate of the two groups was similar. Conclusion Concurrent chemo-radiotherapy in locally advanced NSCLC can increase the recent effect. The concurrent treatment method of docetaxel + three-dimensional conformal radiotherapy is advocated.
