Long term clinical outcome of treating patients with nasopharyngeal carcinoma by combined induction chem-otherapy and hyperfractionated radiotherapy
- VernacularTitle:诱导化疗加超分割放疗治疗鼻咽癌的长期结果分析
- Author:
Zhiyuan XU
;
Lianxing LIN
;
Zuoming CHEN
;
Junxi YANG
- Publication Type:Journal Article
- Keywords:
Nasophoryngeal neoplasms;
Remission induction;
Brachytherapy;
Dose ffactionation;
Prognosis
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(z2):1-2
- CountryChina
- Language:Chinese
-
Abstract:
Objective To approach the therapeutic effects and complication of combined induction chemo-therapy and hyperfraetionated radiotherapy for nasopharyngeal carcinoma.Methods Form January 2000 to November 2002,101 patients with nasopharyngeal carcinoma were treated by combined induction chemotherapy and hyperfrac-tionated radiotherapy.For hyperfraetionated radiotherapy,y-ray from 60 Co were performed and two daily fractions of 1.2Gy were given,with an interval of≥6 hours,5 days per week to a median dose of 7255cGy for nasopharynx and 7201cGy for neck.For induction chemotherapy,carboplatin and 5-fluorouraeil were transfused.Results The inci-denee rate of greater than or equal to the third grade acute mucositis was 24.8%.The complete remission rate after treatment was 83.2%.The 1,2 and 5 year survival rate was 90.1%,82.2%-and 57.4%.Conclusion With this treatment schedule,patient's tolerance and therapeutic effect is good.It provids a treatment means for nasopharyngeal carcinoma.But it must be validated by the large-scale clinical trials.
