Short and long term clinical outcome of 283 cases of nasopharyngeal carcinoma patients treated with hy-perfractionated radiotherapy
- VernacularTitle:283例鼻咽癌超分割放疗的近远期临床疗效分析
- Author:
Zhiyuan XU
;
Hanxing LIN
;
Xiaoping ZHANG
;
Yixuan LI
- Publication Type:Journal Article
- Keywords:
Nasopharyngeal neoplasms;
Radiotherapy;
Radiation injuries;
Prognosis
- From:
Journal of International Oncology
2008;35(9):711-713
- CountryChina
- Language:Chinese
-
Abstract:
Objective To approach the therapeutic effects and complication of hyperfractionated radio-therapy for nasopharyngeal carcinoma. Methods From January 2000 to November 2002,283 patients with na-sopharyngeal carcinoma were treated with hyperfraetionated radiotherapy. For hyperfractionated radiotherapy,γ-ray from 60Co was performed and two fractions of 1.2 Gy were given daily,with an interval of≥6 h,5 days per week to a median dose of 72 Gy for nasopharynx and 68.4 Gy for neck. For some patients, carboplatin or cispla-tin and 5-fluorouracil were transfused. Results The incidence rate of≥3 grade acute mueositis was 12. 4%.The complete remission rate after treatment was 93.6%. The 1,2 and 5 year survival rate was 93.6% ,82. 7%and 60. 1% respectively. Conclusion patients treated with hyperfractionated radiotherapy have good tolerance and therapeutic effect. It provids a treatment means for nasopharyngeal carcinoma. But it must be validated by the large-scale clinical trials.
