The establishment of an arterialized liver transplantation model in mice
- VernacularTitle:重建肝动脉血供的小鼠原位肝移植模型的建立
- Author:
Yujun ZHANG
;
Geng CHEN
;
Xiaowu LI
;
Cheng YANG
;
Shuguang WANG
;
Ping BIE
;
Kun LI
;
Jiahong DONG
- Publication Type:Journal Article
- Keywords:
Liver transplantation;
Animal experimentation;
Revascularization
- From:
Chinese Journal of General Surgery
2008;23(7):503-506
- CountryChina
- Language:Chinese
-
Abstract:
Objective To establish a stable orthotopic liver transplantation(OLT)model with hepatic artery reconstruction in mice.Methods Of the 66 OLT mice,33 recipient mice underwent conventional 'two cuff' technique without hepatic artery reconstruction(control group),33 with hepatic artery reconstruction using 'stent' technology(experimental group).Results The 2 week posttransplant survival rate was 84.85%(28/33)and 81.82%(27/33)in the arterialized and nonarterialized groups respectively.Serum γ-GT and ALP level of arterialized recipient were much lower than those of nonarterialized animals.The pathology of the donor liver showed that rearterialization helps to relieve bile duct injury of liver allograft.Conclusions The hepatic artery supply plays a central role in preventing bile duct injury after transplantation.This mouse OLT model may meet the need for the study of problems associated with liver transplantation.
