Effects of stress stimulation on repair process of rotator cuff tear

VernacularTitle:应力刺激在肩袖损伤修复中作用机制的实验研究
Author: Lei WANG ; Tao LUO ; Lianfu DENG
Publication Type:Journal Article
Keywords: Shoulder; Tendinopathy; Reconstructive surgical procedures
From: Chinese Journal of Orthopaedic Trauma 2009;11(2):152-156
CountryChina
Language:Chinese
Abstract: Objective To explore the role and mechanism of stress stimulation in the repair process of the rotator cuff. Methods The supraspinatus tendon was cut off at the osteotendinous junction (OTJ) and then sutured in situ (Carpenter's model). The experimental group started treadmill running after one week immobility, and the control group were free in the cage. All animals were sacrificed at 4 time points (2, 4, 8 and 16 weeks after operation). Histological changes, immunohistology of yon Willebrand factor and tenascin-C at OTJ were compared between the 2 groups. Results There was no significant difference between the 2 groups in the early repair period. Significant differences between the 2 groups in histology and angiogenesis appeared 8 weeks after operation, and significant differences in expression Of Tenascin-C appeared 16 weeks after operation. Conclusion As stress stimulation can promote angiogenesis and expression of Tenascin-C at OTJ, facilitating the reconstruction of bone and tendon, it plays a critical role in the repair process of rotator cuff tear.