The Effects of Shenyankangfupian on the expression of macrophage migration inhibitory factors in children with henoch-schoeulein purpura nephritis

VernacularTitle:肾炎康复片对紫癜性肾炎患儿尿巨噬细胞移动抑制因子表达的影响
Author: Ruiqing ZHAO
Publication Type:Journal Article
Keywords: Nephritis; Maerophage migration inhibitory factors; Shenyankangfupian
From: Chinese Journal of Primary Medicine and Pharmacy 2009;16(2):237-238
CountryChina
Language:Chinese
Abstract: Objective To investigate the effects of Shenyankangfupian on the expression of macrophage migration inhibitory factors(MIF) in children with henoch-schoenlein purpura nephritis(HSPN).Methods Sixty children with HSPN were divided into two groups randomly.Patients in the control group(n=30) receivded routine therapy for 3 months,and those in the treatment group(n=30) receivded routine therapy plus Shenyankangfupian.Clinical symptoms and the MIF variation were assessed.Results Blcod and protein in urine following Shenyankangfupian therapy were markedly reduced in the treatment group (P＜0.05 ).Compared with the control group (0.68 ± 0.23 ) g/24 h,protein in urine in the treatment group (0.31 ± 0.16 ) g/24 h indicated a statistical significance (P＜0.05 );There is also a statistical difference(P＜0.05) in MIF between the treatment group(2.54 ± 1.06) ng/L and the control group(2.97 ± 1.14) ng/L.Conclusion Shenyankangfupian could markedly relieve symptoms in children with HSPN by mitigating the expression of MIF thus reducing protein in urine.