Outcome of three-dimensional conformal radiation therapy and intensity-modulated radiation therapy for inoperable locally advanced pancreatic cancer
10.3760/cma.j.issn.1004-4221.2009.02.120
- VernacularTitle:41例局部晚期不可手术胰腺癌三维适形或调强放疗的临床分析
- Author:
Ningning LU
;
Jing JIN
;
Yexiong LI
;
Zihao YU
;
Xinfan LIU
;
Weihu WANG
;
Shulian WANG
;
Yongwen SONG
;
Yueping LIU
- Publication Type:Journal Article
- Keywords:
Pancreatic neoplasms/radiotherapy,intensity-modulated and conformal;
Pancreatic neoplasms/radio-chemotherapy,concurrent;
Treatment outcome
- From:
Chinese Journal of Radiation Oncology
2009;18(2):120-123
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the outcome of radiotherapy for locally advanced pancreatic cancer. Methods From January 2000 to December 2007,41 patients with inoperable locally advanced (stage Ⅲ) pancreatic cancer were treated with three-dimensional conformal radiation therapy(3DCRT) or intensity-modulated radiation therapy (IMRT). Among these patients, 30 received concurrent radio-chemo-therapy. Results The median survival time(MST) and 1-year overall survival were 9.2 months and 23%. Patients with pretreatment KPS≥80 ,no regional lymph nodes metastasis, and CR/PR after radiotherapy had better prognosis. The corresponding MSTs were 11.1 months vs 5.8 months (χ2 = 7.50, P = 0.006), 10. 8months vs 6.5 months (χ2 = 5.67, P = 0.017), and 19.5 months vs 9.1 months (χ2= 7.28, P = 0. 007), re-spectively. Concurrent radio-chemotherapy tended to improve the overall survival (χ2 = 3.25, P = 0. 072). After radiotherapy, 18 patients had clinical benefit response, mainly being abdominal pain relief. Neither grade 4 hematologic nor grade 3 non-hematologic toxicities were observed. Conclusions For patients with locally advanced pancreatic cancer, both 3DCRT and IMRT are effective in alleviation of disease-related symptoms. Patients with better porformance status before treatment, no regional lymph nodes metastasis, and better response to radiotherapy may have better prognosis. Concurrent radio-chemotherapy trend to improve overall survival when compared with radiotherapy alone.
