Application of proteomics in the studies of cerebral ischemic preconditioning
10.3760/cma.j.issn.1673-4165.2009.01.016
- VernacularTitle:蛋白质组学在脑缺血预适应研究中的应用
- Author:
Mei LIU
;
Xiaohong CHEN
- Publication Type:Journal Article
- Keywords:
proteomics;
cerebral ischemia;
preconditioning;
two-dimensional electro-phoresis;
mass spectrometry
- From:
International Journal of Cerebrovascular Diseases
2009;17(1):63-66
- CountryChina
- Language:Chinese
-
Abstract:
Proteome is defined as all proteins expressed in a cell, a tissue or an organism. Proteomics, a science of understanding the life activity law at the whole protein level, takes proteome as a research object; it is also a scientific method for quantitative detection of one or more protein populations or proteomes in a cell or tissue. Cerebral ischemic preconditioning has been one of the research hotspots in the field of neuroscience for decades. Its neuroprotec-five mechanism is associated with the changes of protein expression levels after cerebral ischemia, Therefore, proteomics has become more and more important in its mechanism study. This article mainly presents the major techniques of proteomics and their application in the studies of cerebral ischemic preconditioning.
