Effects of intrahepatic injection with hepatocyte growth factor and dexamethason on stereological quantitative changes of hepatic sinusoidal disease and expression of IV-collagen on hepatic sinusoidal walls
10.3760/cma.j.issn.1008-6706.2009.02.008
- VernacularTitle:肝脏注射促肝细胞生长素和地塞米松对肝硬化肝窦病变及Ⅳ型胶原表达的影响
- Author:
Tilong DING
;
Yong MA
;
Fuhua YUAN
;
Jiachun YAN
- Publication Type:Journal Article
- Keywords:
Stereological analysis;
Collagen type IV;
Liver cirrhosis;
Hepatocyte growth factor;
Dexamethasone
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(2):207-208
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the effects of intrabepatic injection with bepatocyte growth factor and dexamethason on stereological quantitative changes of hepatic sinusoidal tissues and expression of IV-collagen on hepatic sinusoidal walls of patients with hepatic cirrhosis.Methods Under the guide of hypersound,98 cases of hepatic cirrhosis were intrahepatic injected with 80mg hepatocyte growth factor and 1mg dexamethason at one time,twice a week,12 times a course,pathological changes of hepatic sinusoidal tissues and the expression of IV-coliagen on hepatic sinusoidal walls were detected by liver biopsy after one course.Results Pathological changes of hepatic sinusoidal tissues were improved obviously(P＜0.01 ) and the expression of IV-collagen was alleviated significantly(P＜0.01 ) on 98cases of hepatic cirrhosis after one course.Conclusion Pathological changes of hepatic sinusoidal tissues and the expression of IV-collagen on hepatic sinusoidal wails can be improved obviously on patients with hepatic cirrhosis who had been intrahepatic injected with hepatocyte growth factor and dexamethason under the guide of hypersound.
