Effect of PEG-INF alpha-2a(PEG-INF-2a)on patients With chronic hepatitis C
10.3760/cma.j.issn.1008-6706.2009.02.015
- VernacularTitle:聚乙二醇干扰素治疗慢性丙型肝炎疗效观察
- Author:
Huajian ZHOU
;
Xiaoyun YANG
;
Hong ZENG
- Publication Type:Journal Article
- Keywords:
Hepatitis C,chrinic;
Interferons;
Polyethylene glycols
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(2):221-222
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the efficacy of PEG-INF alpha-2a(PEG-INF-2a)on patients with chronic hepatitis C.Methods 60 patients with hepatitis C were included in this study.30 patients were treated with PEGINF-2a(180μg or 135μg/week)and RBV 900mg/d,30 patients were treated with IFNα-2a(5 MIU/qod)and RBV 900 mg/d.The time of treatment was 48 weeks,and all the patients were followed up for 24 weeks after treatment.There was no significant difference between the two groups in pretreatment HCV-RNA,HCV genotype and other clinical data.The main parameters to evaluate the efficacy were virological and biochemical responses.The side effects were intensively observed.Results Sustained vimlogical response(SVR)rate in PEG-IFNα-2a group was significantly higher than that in IFNα-2a group(56.5%and 19.5%respectively,P＜0.01).As the patients were divided according to HCV genotype 1 and high virus load.the SVR rate of PEG-IFNα-2a group Was higher than IFNα-2a group(P＜0.01).However,there was no significant difference between two groups in the patients with non-genotype 1 and low viral load(P=0.664,0.116).Similar side-effects were observed in PEG IFNα-2a group and IFNα-2a group,but the rate of weisht decline and the degree of leukocyte decrease were more significant in PEG IFNα-2a group than in IFNα-2a group(P＜0.01).Conclusion The efficacy of PEG IFNα-2a in the treatment of chromic hepatitis C is superior to that of conventional IFNα-2a,PEG-IFNα-2a had good tolerance and safety profiles.
