Study on oxidative stress parameters and pathogenesis in elderly patients with obstructive sleep apnea syndrome combined with cerebrovascular disease
10.3760/cma.j.issn.0254-9026.2009.03.006
- VernacularTitle:老年阻塞性睡眠呼吸暂停综合征并存脑卒中患者氧化应激指标观察及发病机制探讨
- Author:
Qiang ZHANG
;
Jianli TIAN
;
Baoyuan CHEN
- Publication Type:Journal Article
- Keywords:
Sleep apnea,obstructive;
Cerebrovascular accident;
Vascular endothelial growth factors;
Endothelins;
Nitricoxide
- From:
Chinese Journal of Geriatrics
2009;28(3):193-195
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the concentration changes of vascular endothelial growth factor(VEGF), nitric oxide(NO) and endothelin (ET) in elderly patients with obstructive sleep apnea syndrome (OSAS) combined with eerebrovascular disease.Methods One hundred and thirty-two subjects were divided into four groups: OSAS with cerebrovaseular disease group (OC group), OSAS without cerebrovascular disease group (O group), cerebrovascular disease without OSAS group (C group) and normal control group (N group).The concentrations of VEGF, NO and ET in the plasma were compared in each subgroup.Results The concentration of VEGF was significantly increased in OC group and O group compared with C group and N group[(195.34±56.7)ng/L, (162.34±48.7)ng/L, (156.4 4±51.8) ng/L, (114.1 ± 54.2) ng/L, F= 21.02, P< 0.05].The concentration of NO was increased gradually in OC group, C group, O group and N group[(62.3±4.9)mmol/L,(64.7±5.1) mmol/L, (66.2± 4.2)retool/L, (77.5 ± 6.8) mmol/L, F= 17.35, P<0.05], and the concentration of ET was decreased gradually in OC group, C group, O group and N group[(59.8±9.6)ng/L, (56.5±4.3)ng/L, (54.7±7.9)ng/L, (37.2±8.5)ng/L, F= 4.27, P<0.05].Conclusions The concentrations of VEGF and ET are increased and the concentration of NO is decreased in patients with OSAS.Patients with OSAS combined with cerebrovascular disease have higher VEGF and ET concentrations and lower NO concentration than in patients with simple OSAS.The results indicate that vascular endothelial dysfunction may play an important role in the development of cerebrovascular disease in patients with OSAS.
