Analysis of related factors for osteoporosis in postmenopansal patients with type 2 diabetes mellitus
10.3760/cma.j.issn.0254-9026.2009.03.011
- VernacularTitle:绝经后2型糖尿病患者骨质疏松相关因素分析
- Author:
Chengfu YE
;
Min XIANG
;
Shigui YANG
;
Weiwei ZENG
;
Xianen HUANG
;
Liangmiao CHEN
- Publication Type:Journal Article
- Keywords:
Osteoporosis,postmenopansal;
Diabetes mellitus,type 2;
Interleukin-6
- From:
Chinese Journal of Geriatrics
2009;28(3):210-212
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the morbidity and related factors for osteoporosis in postmenopausal patients with type 2 diabetes mellitus (T2DM).Methods The bone mineral density (BMD) at lumbar vertebrae(L1-4), left femoral neck, femoral trochanter and total hip were measured by dual energy X-ray absorptiometry (DEXA) in 79 postmenopansal patients with T2DM.The patients were divided into two groups: osteoporosis group and non-osteoporosis group.The correlations between BMD and age, course of disease, menopausal age, menopausal duration and body mass index (BMI) were analyzed by multivariate regression analysis.Results There were significantly statistical differences in age, BMI, interleukin 6 (IL-6), osteocalcin and menopause duration between two groups.Linear correlation analysis showed IL-6 was positively correlated with osteoporosis (r=0.260, P=0.020) and glycosylated hemoglobin (GHbAlc) (r=0.259, P=0.023) Logistic regression analysis showed that the morbidity of osteoporosis had an independent positive correlation with age, but an independent negative correlation with BMI.Conclusions In postmenopausal patients with T2DM, age and low BMI are independent risk factors for osteoporosis.
