MR enhancement signs of early breast cancer correlate with MVD and VEGF expression
10.3760/cma.j.issn.1008-6706.2009.02.001
- VernacularTitle:早期乳腺癌核磁共振表现、组织微血管密度分布、血管内皮生长因子表达的意义
- Author:
Yong HUANG
;
Yanwei ZHANG
;
Jianping LI
;
Du XIE
;
Yuan LI
- Publication Type:Journal Article
- Keywords:
Neoplasm,breast;
Magnetic resonance imaging
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(2):193-194
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the relationship between MR enhancement signs with MVD and VEGF expression in early breast carcer or benign lesion,improve the correct diagnosis rate of breast mass.Methods The MR enhancement signs(early enhmcement rate,eurve type of enhancement)of 31 patients with breast cancer and 19 benign lesions were analyzed retrospectively.Results Mean early enhancement rate of 31 neoplasm(20 invasive duet csncer,6 invasive lobule cancer,2 mucous cancer,3 situ lobule caner)were(68.4±14.7)%,enhancement curve type of which manifested as 18 type Ⅰ curve,11 typeⅡcurve and 2 type Ⅲ curve.Mean early enhancement rate of 19 benign mass(11 fibre adenoma,6 cystic hyperplasia,1 angioma,lobular tumor,1 infecmd cyst)were(47.6 ±15.2)%,of which 2 were typeⅠcurve,10 type Ⅱ cnrve and 7 type Ⅲ curve.In early cancer focus,mean MVD and VEGF expression index were 48.2±5.6 and 1.8 ±0.3,while in benign mass they were 30.8 ±6.1,0.9 ±0.3 respectivdy.Condusion Early enhancement rate,MVD and VEGF expression index in malignant focus were higher than those in benign mass,type Ⅰ curves were predominate in malignant lesions,by which early breast cancer could be diagnosed in time.
