Effect of inferior hypothermy on serum TNF and IL-6 in patients with severe cerebral trauma

VernacularTitle:亚低温治疗对重度颅脑损伤患者血清肿瘤坏死因子、白细胞介素-6的影响
Author: Qun HE ; Junjun HUANG ; Jiming CAI ; Nina CHEN
Publication Type:Journal Article
Keywords: Hypothennia,induced; Craniocerebra trauma; Tumor necrosis factor-alpha; Interleukin-6
From: Chinese Journal of Primary Medicine and Pharmacy 2009;16(2):197-198
CountryChina
Language:Chinese
Abstract: Objective To explore the effect of inferior hypothermy treatment on serum TNF and IL-6 in patients with severe cerebral trauma.Methods 46 patients were randomly divided into two groups:inferior hypothermy group(24 C88e8)and normal group(22 cases).There are the same basic treatments within the two groups,in the inferior hypothermy group we also sive them hypothermy treatment rectal temperature:32～34℃ which need to last for nearly 4～5 days,at the same time we give patients the lyric cocktail.the TNF,IL-6 and GCS grades on the lst and 14th day were tested.Results TNF and IL-6 as compared with normal group are higher than the inferior hypothermy group,the differences between the two groups are of statistical significance(P＜0.01).The difference of GCS grades between the two groups are of stafictical significance(P＜0.05).Conclusion The inferior hypothermy tbempy which inhibits TNF and IL-6 releasing after severe cerebral trauma and the following damages plays a very important role in the cerebral trauma therapy.