Changes of vascular endothelial growth factor and tumor necrosis factor-α levels in serum of patients with primary hepatocellur carcinoma
10.3760/cma.j.issn.1008-6706.2009.02.018
- VernacularTitle:原发性肝癌患者血清血管内皮生长因子与肿瘤坏死因子-α的变化
- Author:
Liu YANG
;
Qinglan XIA
- Publication Type:Journal Article
- Keywords:
Carcinoma,hepatocellular;
Vascular endothelial growth factor;
Tumor necrosis factor-α
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(2):227-228
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate vascular endothelial growth factor(VEGF) and TNF-α levels in the serum of patients with primary hepatocellur carcinoma(HCC),and to evaluate their relevance with the development and metastasis of HCC.Methods VEGF and TNF-α levels in serum were examined by enzyme linked immunosorbent assay(ELISA) technology in 87 patients with HCC and 10 healthy individuals.Results Serum VEGF and TNF-α,levels in HCC patients were significantly higher than that in the contorl group.In addition,HCC patients infected with hepatitis virus(including HBV and HCV) showed a remarkable elevation in serum VEGF and TNF-α levels.The VEGF and TNF-α levels in HCC with metastasis were also higher than those without metastasis.Conclusion The serum VEGF and TNF-α levels in HCC patients might serve as the pivotal biological indices that could reflect HCC progressien and metastasis.