Relationship between obesity and serum soluble intercellular adhesion molecule-1 in adolescents
10.3760/cma.j.issn.1671-7368.2009.03.010
- VernacularTitle:青少年肥胖与血清可溶性细胞间黏附分子-1相关性分析
- Author:
Chunming MA
;
Hong ZHANG
;
Qiang LU
;
Shuyi WANG
;
Fuzai YIN
;
Bowei LIU
;
Donghui LOU
;
Xiaoli LIU
;
Rui WANG
;
Guangfei WU
;
Gailing HAN
- Publication Type:Journal Article
- Keywords:
Obesity;
Intercellular signaling peptides and proteins;
Adolescent
- From:
Chinese Journal of General Practitioners
2009;8(3):167-169
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the relationship between obesity and serum soluble intercellular adhesion molectde-1 (sICAM-1) in adolescents. Methods Totally, 158 adolescents aged 13-15 years were divided into three groups based on their body mass index (BMI) , 80 in control group, 44 in overweight group and 34 in obesity group. Height, weight, waist circumference (WC) and blood pressure were measured for all of them and sICAM-1 was assayed from fasting venous blood collected. Results BMI, WC and systolic blood pressure were significantly higher in overweight group than those in control group (P < 0. 01). BMI, WC, systolic blood pressure and diastolic blood pressure were significantly higher in obesity group than those in overweight group (P<0. 05). Level of sICAM-1 was significantly higher in obesity group than that in control group (P <0.05). Their sICAM-1 showed positive correlation with BMI (r = 0.168, P=0.035) and WC (r=0. 179, P =0.025). Multiple linear regression analysis using sICAM-1 as a dependent variable showed that WC (β= 0.009, 95% CI 0. 001-0.018, P=0.025) was an independent predictors for sICAM-1 adjusted for age, sex, BMI and blood pressure. Conclusions Results mentioned above suggest that endothelial dysfunction associates with obesity, particularly with abdominal obesity. sICAM-1 can be used as an early marker of atherosclerosis in adolescents.
