Mechanism of impact of transcranial ultrasound contrast imaging on the blood-brain barrier: an earlier research
10.3760/cma.j.issn.1004-4477.2009.02.025
- VernacularTitle:经颅超声造影对血脑屏障通透性影响机制初探
- Author:
Ping LIU
;
Kaibin TAN
;
Lihui MA
;
Zheng LIU
;
Ping ZHANG
;
Yunhua GAO
- Publication Type:Journal Article
- Keywords:
Ultrasonography;
Microbubbles;
Btood-brain barrier
- From:
Chinese Journal of Ultrasonography
2009;18(2):159-162
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the mechanism of the increased permeability of the blood-brain barrier during transcranial ultrasound contrast imaging. Methods Sprague-Dawhy (SD) rats were performed transcranial ultrasound contrast imaging, the lanthanum nitrate and the evans-blue were used as tracers,the distribution of the tracers were observed and the transports mechanism were also investigated. Results The opening of the tight junction and increased permeability of the cellular membrane were observed after the transcranial ultrasound contrast imaging. Conclusions The main mechanism of the increased permeability of the blood-brain barrier was the opening of the tight junction and increased permeability of the cellular membrane.
