The expression of monocyte chemoattractant protein-1 and CCR2 in tuberculous pleurisy

VernacularTitle:单核细胞趋化蛋白-1及其受体在结核性胸膜炎患者中的表达
Author: Xianying TANG ; Songlin CHEN ; Junmin LUO ; Ning FANG ; Xinsheng YAO
Publication Type:Journal Article
Keywords: Monocyte chemoattractant protein-1; CCR2; Tuberculous pleurisy
From: Clinical Medicine of China 2009;25(3):273-275
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression of monocyte chemoattractant protein-1(MCP-1)and CCR2 in peripheral blood and pleural fluid of tuberculous pleurisy patients.Methods Flow cytometry was used to detect the expression of CCR2 in the peripheral blood mononuclear cell and pleural fluid cell of tuberculous pleurisy patients;ELISA was used to detect the content of MCP-1 in serum and pleural fluid.Results MCP-1 in surem and pleural fluid and CCR2 in the peripheral blood mononuclear cell and pleural fluid cell of tuberculous pleurisy patients was significantly higher than that of the healthy normal controls[MCP-1:(340.8±220.8)and(9.0±3.8)ng/L,P＜0.01;CCR2(18.2±10.1)%and(6.9±3.5)%,P＜0.05];Both MCP-1 and CCR2 were detected in pleural fluid and both of them were positivley correlated(r=0.227,P＜0.05).Conclusion The expression of MCP-1 and CCR2 in peripheral blood of tuberculous pleurisy patient are significantly elevated which are significance molecule participating in the pathogenesis of tuberculous pleurisy.