Advance in research of microRNA's application and relationship between microRNA and tumor
10.3760/cma.j.issn.1673-4203.2009.03.015
- VernacularTitle:MicroRNA与肿瘤的关系及其应用的研究进展
- Author:
Wei CHEN
;
Guihua CHEN
- Publication Type:Journal Article
- Keywords:
miRNA;
tumor;
biomarker;
gene therapy
- From:
International Journal of Surgery
2009;36(3):182-185
- CountryChina
- Language:Chinese
-
Abstract:
MicroRNA(miRNA)is a kind of 22 nt endogenous small non-coding single strand RNA and is universally present in animals and plants.It can suppress the expression of target genes at post-transcription al level by complementary biding to the 3'UTR of target mRNAs.Recent studies indicate that microRNA is closely associated with tumorigenesis,differentiation,metastasis and relapse.MicroRNA might act as a new biomarker of tumor diagnosis and a new target of tumor gene therapy.
