Effects of statins on inflammatory reaction in chronic renal failure patients
- VernacularTitle:他汀类药物对慢性肾功能衰竭患者炎性反应的影响
- Author:
Yuan YUAN
;
Keliang SU
;
Wei CHEN
- Publication Type:Journal Article
- Keywords:
Chronic renal failure;
C-reactive protein;
Fibrnogen;
Ststins
- From:
Chinese Journal of Primary Medicine and Pharmacy
2008;15(8):1327-1328
- CountryChina
- Language:Chinese
-
Abstract:
Objective To observe the changes of serum CRP and plasma Fg in patients with chronic renal failure(CRF),to explore the effect of statins on inflammaory reaction in CRF patients.Methods 54 patients with CRF were randomly divided into non-statins group(routine therapy);atstina group(routine therapy plus simvastatin 20mg/d or pravastatin 20mg/d).Besides,a healthy control group consisted of 20 subjects was set up as control group.The changes of serum of CRP and plasma Fg of all groups before and four weeks after treatment were recorded.Results The serum CRP and plasma Fg levels increased in CRF patients,Which were significantly higher as compared to the control group.After treatment for four weeks,the level of CRP,Fg of matins group decreased significantly.The levels of CRP,Fg had no statistical changes in non-statins group.As compared to non-statins group,the differences of CRP,Fg levels after treatment in statins group were statistically significant respectively.Conclusions(1)Inilammaory reaction is a common condition in non-dialysis patients with CRF;(2)ststins show effects on decrease of CRP,Fg level in CRF patients,independently on the effect of decreasing hypedipemia.
