Effects of angiotensin converting enzyme gene polymorphism on endothelial function in patients with essential hypertension
- VernacularTitle:血管紧张素转换酶基因多态性对高血压患者肱动脉内皮舒张功能的影响
- Author:
Lihua ZHAI
;
Shayan WANG
;
Ying WU
;
Ruanzhang ZHANG
;
Chunyu YANG
;
Zengying WANG
;
Yuhua HU
- Publication Type:Journal Article
- Keywords:
Hypertension;
Peptidyl-dipeptidase A;
Genotype;
Endothelium,Vascular
- From:
Chinese Journal of General Practitioners
2008;7(9):606-609
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate effects of angiotensin converting enzyme (ACE) gene insertion/deletion (I/D) polymorphism on endothelial function in elderly patients with essential hypertension. Methods Seventy-three elderly patients with uncomplicated essential hypertension and 55 normal elderly people as control were recruited into the study. Their humeral arterial endothelial vasodilatation function was studied with high-resolution ultrasonography and ACE I/D genotypes were determined by polymerase chain reaction (PCR) technique. Results Endothelium-dependent vasodilatation function of the three-genotype subgroups of the elderly patients with essential hypertension was significantly lower than that in the controls with the same genotypes (5.5±1.9 vs 11.9±1.3 in Ⅱ genotypa, 4.7±2.0 vs 10.9±1.6 in ID genotype and 2.9±1.9 vs 9.4±2.6 in DD genotype, with all P<0.01 ). In both groups of hypertensives and normotensives, humeral arterial endothelium-dependent vasedilatation function was significantly lower in those with DD genotype than that in those with Ⅱ genotype (2.9±1.9 vs 5.5±1.9 in hypertensive group and 9.4±2.6 vs 11.9±1.3 in control group, both P<0.05 ). Multivariate linear regression analysis showed that endothelium-dependent vasodilatation function in hypertensive elderly people correlated in linearity with their ACE genotype (P<0.01 ). Conclusions ACE gene I/D polymorphism is associated with abnormal humeral arterial endothelium-dependent vasodilatation function of humeral artery in patients with essential hypertension.
