Deep fungal infectious in patients with systemic lupus erythematosus:a clinical analysis

VernacularTitle:系统性红斑狼疮合并深部真菌感染临床分析
Author: Xiao CHEN ; Rui FU ; Jie XU ; Xiaofeng ZENG ; Xiaojun MA
Publication Type:Journal Article
Keywords: Lupus erythematosus,systemic; Fungal infection; Mortality; Aspergillus species
From: Chinese Journal of Rheumatology 2009;13(3):159-161
CountryChina
Language:Chinese
Abstract: Objective To investigate the infection sites,the offending species,diagnosis and prognosis of deep fungal infections (DFI) in patients with systemic lupus erythcmatosus (SLE).Methods Fifty-one patients with fungal infections in 1466 SLE patients admitted to Peking Union Medical College (PUMC) Hospital from 2000 to 2006 were reviewed retrospectively.Results Candida albicans was ranked the first pathogen,followed by ncoformans and Aspergillus species.The infection sites were lungs,cerebral meninges and blood in the order of prevalence.The overall mortality was 20%(10/51).Aspergillasis carried the highest mortality which couht be as high as 80%.Hypoproteinemia,multiple focus of fungal infections,Aspergillasis and fungemia might he the independent risk factor for mortality.Conclusion Candida albicans is the most frequent species of fungal infections in SLE patients.Iungs are the most prevalent location of infection.Earlier diagnosis is important.Special attention should be paid to aspergillasis.