A multicenter,random,open,parallel controlled study on the efficacy and safety of ibuprofen arginate in treating rheumatoid arthritis and knee osteoarthritis
10.3760/cma.j.issn.1007-7480.2009.03.010
- VernacularTitle:精氨洛芬治疗膝骨关节炎和类风湿关节炎的疗效和安全性的多中心随机开放对照研究
- Author:
Xiaomei LENG
;
Fengchun ZHANG
;
Zhanguo LI
;
Xuewu ZHANG
;
Donghai WU
;
Huiqiong ZHOU
;
Lingyun SUN
;
Xiuyan YANG
;
Liuqin LIANG
;
Jieruo GU
;
Jianlin HUANG
;
Xinghai HAN
;
Dongbao ZHAO
;
Shengming DAI
;
Shaomei HAN
;
Tao XU
- Publication Type:Journal Article
- Keywords:
Arthritis,rheumatoid;
Osteoarthritis,knee;
Randomized controlled trials;
Ibuprofen arginate granules
- From:
Chinese Journal of Rheumatology
2009;13(3):175-177
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the clinical efficacy of ibuprofen arginate,a new nonsteroidal antiinflammatory drug,with that of ibuprofen,in patients with rheumatoid arthritis or knee osteoarthritis and to evaluate the safety and tolerability of ibuprofen argihate.Methods This is a muhicenter,random,open,active comparator-controlled,parallel clinical trail in which 171 patients with rheumatoid arthritis or knee osteoarthritis were enrolled.Patients were randomized to 2 groups:400 mg of ibuprofen arginate three times daily and 400 mg of ibuprofen three times daily respectively.Clinical efficacy and safety were evaluated after 4-week treatment.Results Ibuprofen arginate,at dosages of 400 mg three times daily,had shown significant efficacy in relieving pain,tenderness and swelling of joints and there was no significant difference when compared to that of ibuprofen.There was no difference in clinical adverse effects between the two groups and no serious adverse effects were repofled.But ibuprofen arginate could initiate effectiveness more rapidly than ibuprofen in both rheumatoid arthritisand osteoarthritis patients.Conclusion Ibuprofen arginate has the same clinical efficacy and safety profiles as itmprofen in treating rheumatoid arthritis and osteoarthritis.However,its onset is more rapid than ibuprofen.
