The expression and significance of activator protein-1 and matrix metalloproteinases in the human heart post acute myocardial infarction

VernacularTitle:激活蛋白1及基质金属蛋白酶在急性心肌梗死后心脏组织中的表达
Author: Shuanglun XIE ; Jingfeng WANG ; Ruqiong NIE ; Woliang YUAN ; Fei LI ; Yongqing UN
Publication Type:Journal Article
Keywords: Myocardial infarction; Matrix metalloproteinase; Aetivatoing transcription factor-1
From: Chinese Journal of Internal Medicine 2009;48(3):205-207
CountryChina
Language:Chinese
Abstract: Objective To investigate the expression and significance of activator protein-1 (AP-1)and matrix metalloproteinases (MMPs) in acute myocardial infarction (AMI) subjects. Methods Immunohistochemical techniques were used to detect the subunit of AP-1 (c-Jun), MMP-2 and MMP-9 in human AMI and normal heart tissue and the expressions of c-Jun and MMPs were measured with computer image analysis system. Results (1) There were expressions of c-Jun, MMP-2 and MMP-9 in normal heart tissue, mainly in myocardial cells and cardiac fibroblasts, and their expressions in AMI myocardial tissues were all significantly higher than those in normal myocardial tissues (P <0.05). (2) The level of MMP-9expression was significantly and positively correlated with c-Jun in AMI heart tissue (r=0.773, P < 0.01).Conclusions The expressions of AP-1 and MMPs increase in human myocardial infarction. These findings suggest that AP-1 transcription activation pathway and MMPs may play an important role in ventricular remodeling of myocardial infarction.