Adhesion molecules related to metastasis in colon carcinoma

VernacularTitle:结肠癌转移相关细胞黏附分子研究进展
Author: Shouyi SUN ; Xiaoyun HU
Publication Type:Journal Article
Keywords: colon carcinoma; cell adhesion molecules; metastasis
From: International Journal of Surgery 2009;36(3):199-201
CountryChina
Language:Chinese
Abstract: Colon carcinoma is one of the most common malignant neoplasms.The incidence of this disease has been increasing significantly in recent years in China.Ahhough diagnostic and therapeutic methods have been im proved greatly.carcinoma invasion and metastasis are considered to be the main causes of poor prognosis and death. Tumor metastasis is a complicated process with multiple steps and factors.Cell adhesion molecule(CAM)play a very impntant role in this process while it expresses exceptionally or loses its function.CAM is a kind of glycopro tein molecule by the cell synthesis which mediates the intereontact and intercombination between cell and cell or be tween cell and matrix.It takes part in a series of important physiologic and pathologic processes,such as cell signal conduction and activation,cell extension and migration,tumor metastasis and wound healing,and so on.