The change of Connexin43 expression in the heart of diabetic mellitus rats
- VernacularTitle:糖尿病大鼠心肌Cx43的变化及相关性研究
- Author:
Mingjin SUN
;
Zhongyuan WEN
;
Ting HUANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus/PP;
Connexin 43
- From:
Journal of Chinese Physician
2009;11(2):160-163
- CountryChina
- Language:Chinese
-
Abstract:
Objective To study the change of the eonnxin43 expression in the heart of diabetic mellitus rats. Methods STZ-in-dueed diabetic mellitus in rats were developed. The expression of connexin43 in the heart was detected by immunohistochemistry and image analysis, and the heart function was observed by electrophysiolograph and echocardiogram. Results During the course of diabetic mellitus, the expression of connexin43 in the heart of diabetic rats decreased respectively in the 12th week and 24th week (P<0.01). The values of dp/dtmax and + dp/dtmax in group DM in the 12th week and 24th week were lower than that in normal control group respectively (P<0.01), and the LVEF were also decreased (12w P<0.05,24w P<0.01). The analysis of correlation showed that the expression of con-nexin43 in heart were positively correlated with heart function (P<0.05) . Conclusion The expression of Connexin43 evidently de-creased in the hearts of diabetic rats and it is positively correlated with the heart function.
