Expression of MPO and TGF-β1 in Ulcerative colitis
- VernacularTitle:MPO与TGF-β1在溃疡性结肠炎中的表达
- Author:
Yanying WANG
;
Lifang SUN
;
Jing YU
;
Yanfeng WANG
;
Zhiwei YANG
;
Xiaoguang MIAO
;
Peiyi ZHANG
;
Yindong WANG
- Publication Type:Journal Article
- Keywords:
Peroxidase;
Transforming growth factor beta;
Colitis,ulcerative
- From:
Journal of Chinese Physician
2009;11(1):31-33
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression and effect of MP0 and TGF-β1 in ulcerative colitis tissues.Methods The expressions of MPO and TGF-Bl in colonal tissue specimens were determined by immunohistochemistry(two step method)in 37 cases of ulcerative colitis,10 crohng disease and 20 normal mucosa.Results The positive rates of MPO and TGF.B1 were 10％and 20.0％in the normal mucosa,55.0％and 35.O％in crohn's disease,and 89.2％and 86.5％in ulcerative colitis.Expression of MPO and TGF-β1 in the ulcerative colitis were higIIer than that in crohn's disease and normal mucosa(P<0.05),there was correlation between MPO and TGF-β1(r=O.51,P<0.05).Conclusion MPO and FGF-β1 are involved in the pathology of UC,and detection of MPO and TGFβ1 can provide some value to evaluate the conditions of UC.
