Expression of Suvivin and its Correlation with Bd-2 in colon carcinoma
- VernacularTitle:Survivin和bcl-2在结肠癌中的表达及临床意义
- Author:
Yan CHEN
- Publication Type:Journal Article
- Keywords:
Microtubule-associated proteins;
Genes,bel-2;
Colonic neoplasms
- From:
Journal of Chinese Physician
2009;11(1):47-49
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the expression of survivin and bcl-2 in colon carcinoma,and their clinical significance.Methods lmmunohistochemistry method wag employed to inspect the expression of Survivin and Bcl-2 in 20 normal colon tissues and 92 colon carci- nomas.Results Positive staining rate of Survi～n in colon carcinoma and normal colon tissues was 68.5％and O％respectively.And there was a significant statistical difference between them(P<0.01).Overexpressions of Survivin were related to the pathological grade and the Dukes's tage(P<0.01),and closely to lymphatic metastasis of colon carcinoma(P<0.叭).Positive staining rate of Bci-2 in colon carcinoma and normal colon tissues Was 59.8％and 0％respectively,and there Was a significant statistical difference between them(P<0.01).Overexpressions of Bcl-2 were related to the Dukes'stage and lymphatic metastasis of colon carcinoma(P<0.01).There Was a positive relation between them,and the Spearman correlation coefficient r was 0.333,P<0.05.Conclusion Survivin and Bcl-2 are relative to the carcinogenesis,progression and prognosis of colon carcinoma,and they were cooperated witll each other in colon carcinomas.
