Association of serum leptin with intima-media thickness of carotid artery in type 2 diabetes patients
- VernacularTitle:2型糖尿病患者血清瘦素与颈动脉内膜中层厚度的相关性研究
- Author:
Zhenhua LIU
;
Huimin BI
;
Yanju HE
;
Yuguo ZHANG
- Publication Type:Journal Article
- Keywords:
Diabetes mellitus,type 2/PP;
Leptin/BL;
Tunica intima/UA;
Carotid arteries/US
- From:
Journal of Chinese Physician
2009;11(2):151-153
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between serum leptin and carotid intima-media thickness in patients with type 2 diabetes mellitus. Methods 35 patients with type 2 diabetes mellitus (DM) and 16 normal controls were studied. Fasting serum leptin, fasting glucose(FBG), HbAlc, C-peptide, lipide, systolic(SBP), diastolic blood pressure(DBP), body mass index (BMI) and waist circ-umference (WC) were measured in all subjects. The intima-media thickness (IMT) of common carotid artery was measured by high-resolu-tion ultrasound imaging. Results IMT of T2DM was positively correlated with leptin concentration. Conclusion Serum leptin concentra-tion is independently associated with the IMT of carotid artery, which suggest that leptin may be an independent risk factor of atherosclerosis.
