The correlation between serum concentrations of apolipoprotein A V and adiponectin in patients with coronary heart disease
10.3760/cma.j.issn.1673-4904.2009.07.008
- VernacularTitle:冠心病患者载脂蛋白A V与脂联素关系研究
- Author:
Chengyu HE
;
Jieqi LI
;
Xiaoming TANG
;
Jie LIU
- Publication Type:Journal Article
- Keywords:
Coronary disease;
Apohpoprotein A-V;
Dyslipidemias;
Adiponectin
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(7):22-24
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the correlation between serum concentrations of apolipoprotein (Apo) AV and adiponecfin in patients with coronary heart disease (CHD). Method The levels of serum total cholesterol (TC), triglyceride (TG), high-density lipoprotein-cholesterol (HDL-C), low-density lipoprotein-cholesterol (LDL-C) , ApoA I and ApoB were examined in 99 subjects by biochemistry department. Enzyme-linked immunosorbent assay (ELISA) method was used to determine ApoA V and adiponectin. All subjects were divided into CHD group(59 patients) and control group(40 patients). Results The concentration of TG was significantly higher than that in control group [(1.79±1.28) mmol/L vs (1.27±0.79) mmol/L]. The concentrations of HDL-C, ApoA V and adiponectin in CHD group were signifi-cantly lower than those in control group[(1.17±0.25) mmol/L vs (1.29±0.26) mmol/L, (186.71±78.20) μg/L vs (250.29±110.38)μg/L, and (3.81±0.15)mg/L vs (5.33±0.37) mg/L,P<0.05or <0.01]. Serum ApoA V was negatively correlated with TG (r =-0.208, P = 0.040), but positively correlated with HDL-C (r = 0.241, P= 0.016) and adiponectin (r = 0.238, P= 0.018). Conclusions The patients with CHD have decreased serum levels of ApoA V and adiponectin, but increased levels of TG. ApoA V and adiponectin influence the development of CHD.
