Role of an inhibitory receptor CD305 in renal allograft rejection
10.3760/cma.j.issn.1000-6702.2009.03.005
- VernacularTitle:抑制性受体CD305表达在移植肾排斥反应监测中的意义
- Author:
Zhouli LI
;
Ming CAI
;
Liping CHEN
;
Yun ZHANG
;
Zhuwei XU
;
Boquan JIN
;
Bingyi SHI
- Publication Type:Journal Article
- Keywords:
Kidney transplanation;
Graft rejection;
Double monoclonal antibody sandwichenzyme linked immunosorbent assay;
Soluble CD305
- From:
Chinese Journal of Urology
2009;30(3):160-162
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the role of soluble CD305(sCD305)in renal allograft rejection.Methods Concentration of serum sCD305 was detected on 20 healthy volunteers and 153 cases of recipients after kidney transplantation by using double monoclonal antibody sandwich enzyme linked immunosorbent assay.Results In the healthy volunteers and 98 recipients with normal renal funetion,sCD305 was detected at low levels of(4.3±2.3)μg/L and(6.3±3.7)μg/L.In 20 cases of acute rejection and 5 cases of graft loss,serum sCD305 levels were(36.3±14.7)μg/L and(28.8±9.4)μg/L,and significantly higher than those in the healthy volunteers and recipients with normal renal function.Meanwhile,in the 30 cases of chronic rejection and 6 cases under dialysis treatment,the levels of sCD205were(13.1±5.5)ttg/L and(11.2±4.6)μg/L and significantly higher than those in the healthy volunteers and recipients with normal renal function.Conclusions CD305 was presented at high level in the recipients with renal acute or chronic rejection,and it might be a potential marker for monitoring graft rejection after transplantation.
