Screening the serum proteomic patterns of Paget disease with SELDI-TOF-MS
- VernacularTitle:SELDI-TOF-MS技术筛选Paget病患者血清特异性蛋白质的研究
- Author:
Jiguang CHENG
;
Zhibo YANG
;
Minfang ZHU
;
Xiaoli REN
- Publication Type:Journal Article
- Keywords:
Spectrum analysis,mass;
Protein array analysis;
Paget's disease,extramammary/DI;
Diagnosis,differential
- From:
Journal of Chinese Physician
2009;11(2):167-169
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the diagnostic value of surface enhanced laser desorption/ionization time of flight mass spectrom-etry(SELDI-TOF-MS) for Paget disease. Methods The relative contents of serum proteins of 15 healthy people,15 patients with chronic eczema and 20 patients with Paget were detected by Weak cation exchanger protein chip (WCx2) and SELDI-TOF-MS. Results The con-tents of two proteins (3868Da,8876Da) had significant difference in healthy people and Paget disease patients(P<0.01). 291IDa, 3868Da and 5097Da protein peaks had significant difference in chronic eczema and Paget disease(P<0.05). Conclusion It shows great potentiality for early diagnosis and screening the tumor biomarkers of Paget disease with SELDI-TOF-MS.
