Clinical significance of c-erbB-2 and nm 23 expression in gastric cancer
- VernacularTitle:胃癌中C-erbB-2和nm23基因的表达及其临床意义
- Author:
Suzuan CHEN
;
Jing YU
;
Senzhi ZHU
;
Qiuyuan LI
;
Juan ZHANG
;
Min ZHONG
;
Xubin JIN
;
Guanghua GUO
- Publication Type:Journal Article
- Keywords:
Stomach neoplasms/PA;
Genes,erbB-2;
Gene expression
- From:
Journal of Chinese Physician
2009;11(2):170-172
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the relationship between the expression of c-erbB-2 and rim23, and their clinical significance in gastric cancer. Methods The expression of c-erbB-2 and nm23 were detected by using immunohistochemical (SP) method in 85 surgi-cally removed specimens from patients with gastric cancer. Results The expression rate of c-erbB-2 and nm23 were 74.1% (63/85),52.9% (45/85). c-erbB-2 was positively correlated with the location, size and depth of invasion of gastric cancer, but not related with the histological types and lymph node metastasis. The expression rate of nm23 in patients without lymph node metastasis (85.7%) and in stage Ⅰ+Ⅱ (72.7%) was higher than that in patients with lymph node metastasis (42.2%) and in stage Ⅲ + Ⅳ (46.0%). The depth of inva-sion and clinical stage between the patients with c-erbB-2 over-expression and nm23 low-expression were positively related(P<0.01 or P<0.01). Conclusion c-erbB-2 promoted growth and invasion of gastric cancer, and nm23 restrained metastasis of gastric cancer. Both c-erbB-2 and nm23 could be served as predictors for biological behavior of gastric cancer.
