Experimental study of hydroxyapatite/ultra-high molecular weight polyethylene and high-density porous polyethylene used for reconstruction of orbit of rabbits
- VernacularTitle:羟基磷灰石复合人工骨和高密度多孔聚乙烯材料行兔眶壁重建的实验研究
- Author:
Xuefeng PAN
;
Hongfei LIAO
- Publication Type:Journal Article
- Keywords:
Hydroxyapatites/TU;
Bone substitutes/TU;
Polyethylene/TU;
Orbital fractures/TH
- From:
Journal of Chinese Physician
2009;11(2):205-207
- CountryChina
- Language:Chinese
-
Abstract:
Objective To compare the biocompatible and osteconduetian behavior of the high-density porous polyethylene and hydroxyapatite/ultra-high molecular weight polyethylene. Methods Osteoectomy of the upper orbital rim was performed on 60 adult Japan rabbits. The animals were randomly divided into 3 groups with 20 of each. The hydroxyapatite/ultra-high molecular weight polyethylene, high-density porous polyethylene was implanted to the upper orbital defect of the animals in respective group. Animals were sacrificed at the 1st, 2nd, 4th and 8th weeks. Alkaline phosphatase (ALP) and Osteocalcin (OC)in the HDPE and hydroxyapatite/ultra-high molecular weight polyethylene was also detected. Result During the experimental period of 8 weeks, there was no implants extrusion or displacement. Fibrous tissue and new vessels grew into HDPE were obviously elder than those grew into hydroxyapatite/ultra high molecular weight polyethy-lene. Alkaline phosphatase and osteocalcin contents has great difference, HDPE group is the best, followed by HA combination artificial group (P<0.05). Conclusions High-density porous polyethylene and hydroxyapatite/ultra-high molecular weight polyethylene are both good orbital reconstruction materials, they all have good biocompatiblity and osteoconductian, but high-density porous polyethylene is better than hydroxyapatite/ultra-high molecular weight polyethylene in osteoconductian.
