A study of coagulation and fibrinolytic system changes in liver cirrhosis patients with and without portal vein thrombosis
10.3760/cma.j.issn.1673-4904.2009.07.004
- VernacularTitle:肝硬化门静脉血栓形成患者凝血和纤溶系统变化的临床研究
- Author:
Ning YANG
;
Donglei ZHANG
- Publication Type:Journal Article
- Keywords:
Livereirrhosis. Portal vein;
Thrombosis;
D-dimer
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(7):11-13
- CountryChina
- Language:Chinese
-
Abstract:
Objective To investigate the coagulation and fibrinolytie system changes in liver cirrhosis (LC) patients with and without portal vein thrombosis (PVT). Method Twenty-six cases of LC with PVT (PVT group) and 61 eases of LC without PVT (control group) were chosen. Platelet(Pt), prothrpmbin time (PT), activated partial thromboplastin time (APTT), fibrin (Fib), D-dimer, tissue plasminogen activator (t-PA) and plasminogen activator inhibitor-1 (PAI-l) were determined. SPSS 11.5software was used for statistic analysis. Results In PVT group, the average level of D-dimer was (0.97±0.53 ) mg/L,signifieantly higher than that in control group (0.61±0.40) mg/L. No significant difference was found between the two groups in Pt PT, APTT, Fib, t-PA and PAI-1. PT and APTT were progressively prolonged from Child-Pugh grade A to B and then to C. Fib was progressively decreased from Child-Pugh grade A to B and then to C. Decreased Pt and increased t-PA, PAI-1 were found in LC patients, but had no sighifieant difference. Conclusions The changes determined of coagulation and fibrinolytie system in patients with LC are abnormal. The average level of D-dimer is higher in LC patients with PVT than that in LC patients without PVT. D-dimer may be a helpful tool to rule out the presence of an underlying PVT in LC patients.
