Influence of Jianpiyishen Decotion on kidney Fibronectin expression in rats with 5/6 nephrectomy
- VernacularTitle:健脾益肾方对5/6肾切除大鼠肾组织纤维连接蛋白表达的影响
- Author:
Wuyong YI
;
Shudong YANG
;
Jun YANG
;
Airong QI
;
Dong YANG
;
Qing YANG
;
Bu FU
;
Sunmin LIE
- Publication Type:Journal Article
- Keywords:
REINFORCING KIDNEY;
STRENGTHENING SPLEEN;
Kidney failure,chronic/ZD;
Coonnexins
- From:
Journal of Chinese Physician
2009;11(1):8-10
- CountryChina
- Language:Chinese
-
Abstract:
Objective To explore the mechanisln of action of Jianpiyishen Decotion on renal fibrosis and provide experimental evidence for chnieal application.Methods The Wistar male rats were randomly divided into four groups.They were normal control group(N group),model group(M group),low dose treatment group(L group)and high dose treatment group(H group).AⅡanimal models were made of CRF with subtotal renal ablation except the N group.Interference began at one week after operation.After being interfered for 8 weeks,blood serunl and nephridial tissues were taken out.Serum urea nitrogen(BUN)and creatinine(Scr)and fibronectin(FN)were detected.Results In N group。There were light expression in renal tubniointerstitial substance,cellula epithelialis basal meulbnule and Vascular smooth muscle.In M group,FN was strong expressed in renal tubulointerstitial substance and renal tubde,and also in glomerular mesangium.There was significant difference between N and M group(P
