Nerve protection mechanism of acupuncture to the secondary injury in the rat of intercerebral hemorrhage

VernacularTitle:针刺对脑出血大鼠继发性神经损伤保护机制的研究
Author: Fang LIU ; Guowei ZHANG ; Wei ZOU ; Dan LI
Publication Type:Journal Article
Keywords: Acupuncture; Cerebral hemorrhage; Nerve growth factor; Apoptosis; Rat
From: Chinese Journal of Primary Medicine and Pharmacy 2009;16(3):420-422
CountryChina
Language:Chinese
Abstract: Objective Expwre to the mechanism of the function of nerve protection to the secondary injury in the rat of intercerebral hemorrhage by acupuncture.Methods 160 healthy Wistar male rats were selected.The rats were assigned into 3 group randomly:model group,pinprick set,piracetam group.containing 50 rats in each.Each group were again divided into five time phase point of6 hours,1 day,2days,3days,7days.containing 10 rats in each.All rats were made to be the intercerebral hemorrhage model.Another 10 rats were assigned as the control.The pinprick group were acupunctured on the "Baihui" penetrating "Qubin".Results In the pinprick group,the expression 0fNGF of ratg brain dssue surrounding the hematoma was increased gradually and to the peak in 7days with the increasing of different time phase point.In the same time phase point,compare with the model group,the pinprick groupb expression of NGF was higher obviously.Both were relatively showed the significant difference(P＜0.01)and had statistical sigllificanle.Conclusion The therapy of acupuncture Can promote the expression of NGF of the rat'sbrain tissue surrounding the hematoma.