T cell subsets and the related changes in cytokine in children with recurrent respiratory tract infection
10.3760/cma.j.issn.1008-6706.2009.03.024
- VernacularTitle:反复呼吸道感染患儿血清T细胞亚群及相关细胞因子水平的变化
- Author:
Yinghua WANG
- Publication Type:Journal Article
- Keywords:
Respiratory tract infections;
T-lymphocytes;
Cytokines
- From:
Chinese Journal of Primary Medicine and Pharmacy
2009;16(3):429-430
- CountryChina
- Language:Chinese
-
Abstract:
Objectlve To investigate recurrent respiratory tract infection in children with T-cell subsets and related eytokines change.Methods Choose meet the RRTI diagnostic criteria for children and healthy infants,application APAAP double antibody ELISA method and the sandwich method ty detect RRTI other healthy infants and children with the T-lymphocyte subsets and cytokines interferon γ(IFN-γ),interleuldn 10(IL-IO),interleukin 6 (IL-6)levels,and compared,Results Children with recurrent respiratory tract infection of T lymphocyte subsets CD+3,CD+4decreased co;increased serum IL-6(2.5±1.6 ku/L),IL-10(3.1±2.4 ku/L)and IFN-γ(12.6±6.4μg/L)levels were significantly below the healthy group(6.8±4.7 ku/L、7.4±3.5 ku/L、21.5±9.7μg/L)(P＜0.01).Conclusion The boay of the RRTI children humoral and cellular immune existed varying degrees of functional defects.
