Role of Svcam-1 in the pathogenesis of intrahepatic cholestasis of pregnancy

VernacularTitle:可溶性血管细胞黏附分子1在妊娠期肝内胆汁淤积症发病中的作用
Author: Caiyun FANG ; Yanmei FANG ; Lili GUO
Publication Type:Journal Article
Keywords: Cholestasis,intrahepatic; Vascular cell adhesion molecule-1; Pregnancy outcome
From: Chinese Journal of Primary Medicine and Pharmacy 2009;16(3):435-436
CountryChina
Language:Chinese
Abstract: Objoctive To investigate circulating leveh of soluble vascular cell adhesion molecule-1(sVCAM-1)in the peripheral of intrahepatic cholestasis of pregnancy(ICP).To reveal the pathogenesis of ICP.Methods Maternal scram sVCAM-1 levels were determined in 49 women which 15 eases were normal pregnant women and 34 with ICP.The latter were composed of 14 women with mild,20 with severe ICP.sVCAM-1 was measured by ELISA.Results The levels of serum sVCAM-1 was significantly elevated in women with mild and severe compared with control subjects(P＜0.01),and markedly decreased to normal 5 days after dilively(P＞0.05).The sVCAM-1 level were negatively correlated with weight of neonatal(r=-0.643,P＜0.01).Conclusion Elevated levels of sVCAM-1 indicate that a primary endothelial cell dysfunction play an important role in the ICP.And it influences the neonatal.