Protection for regional systolic function of left ventricle by ischemic postconditioning in rabbits with ischemic reperfusion detected by echocardiography
10.3760/cma.j.issn.1004-4477.2009.03.024
- VernacularTitle:超声评价缺血后适应对兔缺血再灌注模型心脏局部收缩功能的保护作用
- Author:
Jinling CHEN
;
Ruiqiang GUO
;
Qing ZHOU
;
Bing WU
- Publication Type:Journal Article
- Keywords:
Echocardiography;
Myocardial ischemia;
Myocardial reperfusion injury;
Ventricular function,left;
Ischemic postconditioning
- From:
Chinese Journal of Ultrasonography
2009;18(3):253-256
- CountryChina
- Language:Chinese
-
Abstract:
Objective To detect cardiac function in rabbits models with isehemic reperfusion and to evaluate the short-term protective effects of ischemic postconditioning on regional systolic function of left ventricle by echocardiography. Methods Twenty-eight rabbits were divided into 2 groups:control group and ischemic postconditioning(IP) group. Echocardiography were performed before tests and 2 weeks after tests. The conventional echocardiography indices included left ventricular end-diastolic diameter(LVDd) ,left ventricular anterior wall end-diastolic thickness (AW) and left ventricular ejection fraction (LVEF). Quantitative tissue velocity imaging and strain rate imaging indices included the peak velocity in systole(Vs) and radial peak strain rate in systole(SRs). Results Before tests, there were no difference in conventional echocardiography indices between the two groups; compared with before test, the two groups had significantly larger LVDd,thiner AW and lower LVEF(P <0.05) ; compared with the controls, the group IP had significantly smaller LVDd, thicker AW and higher LVEF 2 weeks after tests(P<0.05) ; compared with controls, the number of segments with abnormal wall motion in group IP significantly decreased. Before tests,there were no differences in Vs and radial SRs between the two groups; compared with before test,the two groups had significantly lower Vs and radial SRs(P<0.05) ; compared with the controls,Vs and radial SRs in group IP significantly increased 2 weeks after tests (P<0.05). Conclusions Ischemic postconditioning can protect regional systolic function of rabbits models with ischemic reperfusionin in short-term,which can be effectively evaluated by strain rate imaging.
