Three dimensional conformal radiotherapy combined with gemcitabine chemotherapy for locally advanced non-small cell lung cancer
10.3760/cma.j.issn.1673-4904.2009.09.008
- VernacularTitle:适形放疗同步吉西他滨化疗治疗局部晚期非小细胞肺癌临床研究
- Author:
Jiazhu HU
;
Xicheng WANG
;
Fangyun XIE
;
Guorong ZOU
;
Yihua LI
- Publication Type:Journal Article
- Keywords:
Carcinoma,non-small cell lung;
Radiotherapy,computer-assisted;
Drug therapy,combination;
Gemcimbine
- From:
Chinese Journal of Postgraduates of Medicine
2009;32(9):20-23
- CountryChina
- Language:Chinese
-
Abstract:
Objective To evaluate the acute side effects and efficacy of three dimensional conformal radiotherapy (3D-CRT) combined with gemcitabine chemotherapy for locally advanced non-small cell lung cancer (NSCLC). Methods From January 2006 to December 2007, 90 cases with advanced NSCLC were divided into two groups, treatment group of 45 patients were tre.ated with 3D-CRT and gemcitabine, control group of 45 patients were treated with gemcitabine and conventional radiotherapy. Chemotherapy consisted of intravenously gemeitabine 350 mg/m2 on day 1, 8, 15, 22, 29, 36. Radioactive source was used with X ray of 6 MV or 15 MV. Irradiatial target area were lung site and mediastinal node. Results The complete remission (CR)and remission rate(RR) in centrol group were 5 cases (11.1%) and 28 cases(62.2%), but in treatment group were 13 cases (28.9%) and 38 cases (84.4%), respectively. The difference of response rate in two groups was significant(P < 0.05). The rate of acute radiation-induced pneumonifis and esophagitis in control group (28.9%, 35.6%)were higher than those in treatment group (11.1%, 17.8%), there were significant difference between two groups (P < 0.05). Conclusions Concurrent application of gemcitabine and 3D-CRT can improve the RR for locally advanced NSCLC, and the acute toxicity are lower than those of gemcitabine and conventional radiotherapy. The clinical study is needed, but the late effect shoud be followed.
