Clinical observation on effects of leflunomide OH rheumatoid arthritis

VernacularTitle:来氟米特治疗类风湿关节炎的临床观察
Author: Chuanhai ZHANG
Publication Type:Journal Article
Keywords: Arthritis,rheumatoid; Leflunomide; Methotrexate
From: Chinese Journal of Primary Medicine and Pharmacy 2009;16(3):433-434
CountryChina
Language:Chinese
Abstract: Objective To compare the effect and safety of leflunomide(LEF)with those of methotrexate (MTX)in patients with active rheumatoid arthritis(RA).Methods Ninty patients were randomly assigned to receive LEF or MTX.The patients in the treatment group(45 eases)received LEF 20mg/d,and those in the control group(45 cases)received MTX 15 mg/week,totally 24 weeks as a coutse of treatment.Results The total effective mtes of the treatment group and the control group were 93.3%and 91.1%respectively.There Was no significant difference between the two groups in the effectiveness(P＞0.05).The adverse reaction rate was 13.3%(6 cases)in the treatment group and 15.6%(7 cases)in the control group with no significant difference between the two groups (P＞0.05)But the adverse reactions were more tolerable in treatment group than these in control group.Conclusion This study suggests that LEF is an effective drug with minor adverse reactions for active rheumatoid arthritis.