Clinical effects of second biopsy and resection in patients with high risk superficial transitional cell carcinoma of the bladder

VernacularTitle:高危非肌层浸润膀胱尿路上皮癌术后再活检和电切的临床意义
Author: Xiaowen SUN ; Dongliang YAN ; Shujie XIA ; Mingshan YANG ; Bangmin HAN ; Haitao LIU ; Weiguo LI
Publication Type:Journal Article
Keywords: Bladder neoplasms; Carcinoma; Reoperation
From: Chinese Journal of Urology 2009;30(4):248-250
CountryChina
Language:Chinese
Abstract: Objective To explore the effects of second biopsy and resection on tumor recurrence and progression in patients with high risk non-muscle invasive bladder cancer. Methods The second biopsy and resections were performed 4-6 weeks after the first transurethral resection in 52 patients. Routine follow-up was done in another 71 patients. The tumor recurrence and progression rates were compared. Results Residual tumors were found in 54%(28/52) of patients underwent second biop-sy and resection, including muscle-invasive tumors in 5 patients. Two patients underwent radical cys-tectomy due to resection findings. During same period, 71 patients were routinely followed. After a median observation of 27 months, patients underwent second biopsy and resection showed lower recur-rence rate (P<0.05). The progression rate was no difference between the 2 groups(P0.05). Conclusion Second biopsy and resection may reduce recurrence rate in high risk non-muscle invasive bladder cancers, but may not change the tumor progression rate.